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| thu || sep || 25 || introduction to brain mechanics || [http://biomechanics.stanford.edu/me334_14/me334_s02.pdf s02] || | | thu || sep || 25 || introduction to brain mechanics || [http://biomechanics.stanford.edu/me334_14/me334_s02.pdf s02] || | ||
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| − | | tue || sep || 30 || | + | | tue || sep || 30 || dissecting brains || [http://biomechanics.stanford.edu/me334_14/me334_s03.pdf s03]|| |
|- | |- | ||
| − | | thu || oct || 02 || | + | | thu || oct || 02 || brain anatomy - student presentations || [http://biomechanics.stanford.edu/me334_14/me334_s04.pdf s04] || |
|- | |- | ||
| − | | tue || oct || 07 || | + | | tue || oct || 07 || brain mechanics in 1d – elasticity of neurons || [http://biomechanics.stanford.edu/me334_14/me334_s05.pdf s05] || |
|- | |- | ||
| − | | thu || oct || 09 || | + | | thu || oct || 09 || brain mechanics in 3d – elasticity of the brain || [http://biomechanics.stanford.edu/me334_14/me334_s06.pdf s06] || |
|- | |- | ||
| − | | tue || oct || 14 || | + | | tue || oct || 14 || brain mechanics in 3d – viscoelasticity of the brain || [http://biomechanics.stanford.edu/me334_14/me334_s07.pdf s07] || |
|- | |- | ||
| − | | thu || oct || 16 || | + | | thu || oct || 16 || brain mechancis in 3d – poroelasticity of the brain || [http://biomechanics.stanford.edu/me334_14/me334_s08.pdf s08] || |
|- | |- | ||
| − | | tue || oct || 21 || | + | | tue || oct || 21 || brain growth in 1d – axonal growth || [http://biomechanics.stanford.edu/me334_14/me334_s09.pdf s09] || |
|- | |- | ||
| − | | thu || oct || 23 || | + | | thu || oct || 23 || brain growth in 2d – morphogenesis || [http://biomechanics.stanford.edu/me334_14/me334_s10.pdf s10] || |
|- | |- | ||
| − | | tue || oct || 28 || | + | | tue || oct || 28 || brain growth in 3d – physiology and pathology || [http://biomechanics.stanford.edu/me334_14/me334_s11.pdf s11]|| |
|- | |- | ||
| − | | thu || oct || 30 || | + | | thu || oct || 30 || brain growth in 3d – pathologies || [http://biomechanics.stanford.edu/me334_14/me334_s12.pdf s12] || |
|- | |- | ||
| − | | tue || nov || 04 || | + | | tue || nov || 04 || brain growth in 3d – brain tumors || [http://biomechanics.stanford.edu/me334_14/me334_s13.pdf s13] || |
|- | |- | ||
| − | | thu || nov || 06 || | + | | thu || nov || 06 || brain fluid mechanics – hydrocephalus || [http://biomechanics.stanford.edu/me334_14/me334_s14.pdf s14] || |
|- | |- | ||
| − | | tue || nov || 11 || | + | | tue || nov || 11 || brain dynamics in 1d - axonal injury || [http://biomechanics.stanford.edu/me334_14/me334_s15.pdf s15] || |
|- | |- | ||
| − | | thu || nov || 13 || | + | | thu || nov || 13 || neurosurgery - brain doctors || [http://biomechanics.stanford.edu/me334_14/me334_s16.pdf s16] || |
|- | |- | ||
| − | | tue || nov || 18 || | + | | tue || nov || 18 || brain dynamics in 3d - traumatic brain injury || [http://biomechanics.stanford.edu/me334_14/me334_s17.pdf s17] || |
|- | |- | ||
| − | | thu || nov || 20 || | + | | thu || nov || 20 || brain dynamics in 3d – shaken baby syndrome || [http://biomechanics.stanford.edu/me334_14/me334_s18.pdf s18] || |
|- | |- | ||
| tue || dec || 02 || final projects - discussion, presentation, evaluation || [http://biomechanics.stanford.edu/me334_14/me334_s19.pdf s19] || | | tue || dec || 02 || final projects - discussion, presentation, evaluation || [http://biomechanics.stanford.edu/me334_14/me334_s19.pdf s19] || | ||
Revision as of 22:33, 10 September 2014
Contents |
fall 14 - me334 - mechanics of the brain
|
me 337 - mechanics of the brain 14 ellen kuhl fall 2014 |
goals
understanding the role of mechanics in brain development, physiology, and pathology. mechanics of brain cells: neurons, mechanobiology, mechanotransduction. mechanics of brain tissue: experimental testing, constitutive modeling, computational modeling. mechanics of brain development: gyrification, cortical folding, axon elongation, lissencephaly, polymicrogyria. mechanics of traumatic brain injury: high impact loading, neural injury. mechanics of brain tumors, brain cancer, tumor growth, altered cytoskeletal mechanics. mechanics of neurological disorders: autism, dementia, schizophrenia. mechanics of brain surgery.
grading
- 20 % dissection - presentation and written report, 10% each
- 30 % homework - three homework assignments, 10% each
- 20 % project presentation - graded by the class
- 30 % project report - graded by instructor
syllabus
| day | date | topic | slides | homework | |
|---|---|---|---|---|---|
| tue | sep | 23 | introduction to brain anatomy | s01 | |
| thu | sep | 25 | introduction to brain mechanics | s02 | |
| tue | sep | 30 | dissecting brains | s03 | |
| thu | oct | 02 | brain anatomy - student presentations | s04 | |
| tue | oct | 07 | brain mechanics in 1d – elasticity of neurons | s05 | |
| thu | oct | 09 | brain mechanics in 3d – elasticity of the brain | s06 | |
| tue | oct | 14 | brain mechanics in 3d – viscoelasticity of the brain | s07 | |
| thu | oct | 16 | brain mechancis in 3d – poroelasticity of the brain | s08 | |
| tue | oct | 21 | brain growth in 1d – axonal growth | s09 | |
| thu | oct | 23 | brain growth in 2d – morphogenesis | s10 | |
| tue | oct | 28 | brain growth in 3d – physiology and pathology | s11 | |
| thu | oct | 30 | brain growth in 3d – pathologies | s12 | |
| tue | nov | 04 | brain growth in 3d – brain tumors | s13 | |
| thu | nov | 06 | brain fluid mechanics – hydrocephalus | s14 | |
| tue | nov | 11 | brain dynamics in 1d - axonal injury | s15 | |
| thu | nov | 13 | neurosurgery - brain doctors | s16 | |
| tue | nov | 18 | brain dynamics in 3d - traumatic brain injury | s17 | |
| thu | nov | 20 | brain dynamics in 3d – shaken baby syndrome | s18 | |
| tue | dec | 02 | final projects - discussion, presentation, evaluation | s19 | |
| thu | dec | 04 | final projects - discussion, presentation, evaluation | s20 | |
| fri | dec | 05 | final project reports due |
matlab files
finally... here's the matlab code for brain folding
additional reading
(1) taber l. biomechanics of growth, remodeling, and morphogenesis, appl mech rew 48, 487-545, 1995
(2) kuhl e, menzel a, steinmann p. computational modeling of growth - a critical review, a classification and two new consistent approaches, computational mechanics 32, 71-88, 2003
(3) rodriguez ek, hoger a, mc culloch a. stress-dependent finite growth in soft elastic tissues, j biomechanics 27, 455-467, 1994
(4) kuhl e, maas r, himpel g, menzel a. computational modeling of arterial wall growth - attempts towards patient-specific simulations based on computer tomography, biomech model mechanobio 6, 321-331, 2007
(5) göktepe s, abilez oj, parker kk, kuhl e. a multiscale model for eccentric and concentric cardiac growth
through sarcomerogenesis.j theor bio 265: 433-442, 2010
(6) ambrosi d, ateshian ga, arruda em, cowin sc, dumais j, goriely a, holzapfel ga, humphrey jd, kemkemer r, kuhl e, olberding je, taber la, garikipati k. perspectives on biological growth and remodeling.j mech phys solids 59: 863-883, 2011
(7)
zöllner am, buganza tepole A, kuhl e. on the biomechanics and mechanobiology of growing skin. j theor bio 297, 166-175, 2012
(8) menzel a, kuhl e. frontiers in growth and remodeling. mech res comm 42,1-14, 2012