living matter lab
in the news

simulation of complex brain surgery with a personalized brain model benchmark feature
a physical model for neurodegenerative disease physics focus
stanford-led team simulates how alzheimer’s disease spreads through the brain stanford report
4 awesome discoveries you probably didn't hear about this week nsf
connecting the dots of alzheimer’s disease scope feature aimbe feature
model maps domino effect of alzheimer’s protein misfolding futury
team simulates how alzheimer's disease spreads through the brain newsline 17ok
video shows how alzheimer's might kill brain cells newsweek
new research may totally turn understanding of dementia on its head biospace
how alzheimer's spreads in brain captured by computer model newsmax
new simulation shows how alzheimer’s spreads my science
researchers model how toxic proteins course through the brain stevens news
digital brain model reveals how toxic proteins cause brain diseases medindia
researchers model how toxic proteins course through the brain, lead to disease
this is a brain taken over by alzheimer's gizmodo
un modele informatique simule la facon dont la maladie d’alzheimer se propage recherche
Ученые визуализировали развитие нейродегенеративных заболеваний n+1
mechanical forces may underlie brain's development and some diseases stanford report
gehirnmechanik? gamm rundbrief 01/18
skin wrinkling featured on the cover of soft matter soft matter
hyperion innovation excellence award goes to ubercloud and stanford living heart project inside hpc
hpc wire editors' choice award for best use of hpc in the cloud hpc wire drug paper
stanford and ubercloud take living heart simulations to the cloud uber cloud
physical model of skull growth prl focus
geometry, skull growth and brain mechanics
stanford researchers design new brain simulation tool youtube
stanford simulator predicts brain swelling to guide surgeons engadget
new brain simulator helps surgeons plan operations i4u
the inner strain on the brain stanford report, science blog, phys org
maths gives insights into damage during brain surgery oxford science blog, neuroscience news
simulating inner strain that causes brains to bulge physics world
when the brain bulges physics buzz
understanding damage during brain surgery oxford math
unfolding the brain feature on brain folding, brains, and more brains, und gehirne
feature on our bioX seed grant on stanford scope
research within the living heart project living heart video, on 3ds youtube
computing the gut biomedical computation review
international brain mechanics and trauma lab ibmtl video
mechanical engineering magazine the digital heart
boston globe living heart project brings a beat to 3d
american physical society - spotlight exceptional research getting the wrinkles out
the living heart project - emily's story the living heart project
simulating stanford students community news
skin growth's role in reconstructive surgery simbios video
researchers envision switching a heart beat on and off with light NSF discovery
frontiers in growth and remodeling advances in engineering
the science of light and vision AAAS science update 11/04/11
light-based pace maker AAAS science update 11/16/11
first human heart cells that can be paced with light here
das herz schlägt heller deutschlandfunk 01/04/12 full text
under the hood biomedical computation review spring 2011
check out our stanford e14 statics course on youtube here
and the eth zurich statics version here


Weickenmeier J, Jucker M, Goriely A, Kuhl E. A physics-based model explains the prion-like features of neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. J Mech Phys Solids. 2019; 124: 264-281. (open access) (download)

Sahli Costabal F, Matsuno K, Yao J, Perdikaris P, Kuhl E. Machine learning in drug development: Characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and uncertainty quantification. Comp Meth Appl Mech Eng. 2019; doi:10.1016/j.cma.2019.01.033. (open access) (download)

Harris TC, de Rooij R, Kuhl E. The shrinking brain: Cerebral atrophy following traumatic brain injury. Ann Biomed Eng. 2018; doi:10.1007/s10439-018-02148-2. (open access) (download)

Sahli Costabal F, Yao J, Sher A, Kuhl E. Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure response simulator. Prog Biophys Mol Bio. 2018; doi:10.1016/j.pbiomolbio.2018.10.003. (download)

Sahli Costabal F, Choy JS, Sack KL, Guccione JM, Kassab G, Kuhl E. Multiscale characterization of heart failure. Acta Biomat. 2019; 86:66-76. (open access) (download)

Lejeune E, Dortdivanlioglu B, Kuhl E, Linder C. Understanding the mechanical link between oriented cell division and cerebellar morphogenesis. Soft Matter. 2019; doi:10.1039/c8sm02231c. (download)

Ostwald R, Kuhl E, Menzel A. On the implementation of finite deformation gradient-enhanced damage models. Comp Mech. 2019; in press. (download)

Bothe W, Escobar Kvitting JP, Rausch MK, Timek TA, Swanson JC, Liang DH, Walther M, Kuhl E, Ingels NB, Miller DC. Do annuloplasty rings designed to treat ischemic/functional mitral regurgitation alter left-ventricular dimensions in the acutely ischemic ovine heart? J Thor Cardivasc Surg. 2019; doi:10.1016/j.jtcvs.2018.12.077. (download)

Alawiye H, Kuhl E, Goriely A. Revisiting the wrinkling of elastic bilayers I: Linear analysis. Phil Trans A. 2019; doi:10.1098/rsta.2018.0076. (download)


Weickenmeier J, Kuhl E, Goriely A. The multiphysics of prion-like diseases: progression and atrophy. Phys Rev Lett. 2018; 121:158101. (open access) (download) (physics focus) (stanford report) (nsf)
(scope) (aimbe) (futury) ( (newsweek) (biospace) (newsmax) (my science) (stevens) (medindia) ( (gizmodo) (recherche) (n+1)

Holland MA, Budday S, Goriely A, Kuhl E. Symmetry breaking in wrinkling patterns: Gyri are universally thicker than sulci. Phys Rev Lett. 2018; 121:228002. (open access) (download)

Sahli Costabal F, Yao J, Kuhl E. Predicting the cardiac toxicity of drugs using a novel multiscale exposure-response simulator. Comp Meth Biomech Biomed Eng. 2018; 21:232-246. (download) (open access) (hyperion innovation excellence award) (hpc wire editors' choice award)

de Rooij R, Kuhl E. Physical biology of axonal damage. Front Cell Neurosci. 2018; 12:144. (download) (download) (open access)

Kuhl E. Mechanical cues in spinal cord injury. Biophys J. 2018; 115:751-753. (download)

Weickenmeier J, Kurt M, Ozkaya E, de Rooij R, Ovaert TC, Ehman RL, Butts Pauly K, Kuhl E. Brain stiffens post mortem. J Mech Beh Biomed Mat. 2018; 84:88-98. (download) (open access)

de Rooij R, Kuhl E. Microtubule polymerization and cross-link dynamics explain axonal stiffness and damage. Biophys J. 2018; 114:201-212. (download)

Sahli Costabal F, Yao J, Kuhl E. Predicting drug-induced arrhythmias by multiscale modeling. Int J Num Meth Biomed Eng. 2018; 34:e2964. (download)

Weickenmeier J, Kurt M, Ozkaya E, Wintermark M, Butts Pauly K, Kuhl E. Magnetic resonance elastography of the brain: A comparison between pigs and humans. J Mech Beh Biomed Mat. 2018; 77:702-710. (download)

Limbert G, Kuhl E. On skin microrelief and the emergence of expression microwrinkles Soft Matter. 2018; 14:1292-1300. (download)

de Rooij R, Kuhl E. A physical multifield model predicts the development of volume and structure in the human brain. J Mech Phys Solids. 2018; 112: 563-576. (download) (movie01) (movie02)

de Rooij R, Kuhl E, Miller, KE. Modeling the axon as an active partner with the growth cone in axonal elongation. Biophys J. 2018; 115:1783-1795. (download)

Lee T, Vaca EE, Ledwon JK, Bae H, Topczewska JM, Turin SY, Kuhl E, Gosain AK, Buganza Tepole A. Improving tissue expansion protocols through computational modeling. J Mech Beh Biomed Mat. 2018; 82:224-234. (download)

Oomen PA, Holland MA, Bouten CVC, Kuhl E, Loerakker S. Growth and remodeling play opposing roles during postnatal human heart valve development. Sci Rep. 2018; 8:1235. (download)

Purnell CA, Gart MS, Buganza Tepole A, Tomaszewski JP, Topczewska JM, Kuhl E, Gosain AK. Determining the differential effects of stretch and growth in tissue-expanded skin: Combining isogeometric analysis and continuum mechanics in a porcine model. Dermatol Surg. 2018; 44:48-52. (download)

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zollner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakides I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC. Passive stretch induces structural and functional maturation of engineered heart muscle as predicted by computational modeling. Stem Cells. 2018; 36:265-277. (download)

Sahli Costabal F, Zaman JAB, Kuhl E, Narayan SM. Interpreting activation mapping of atrial fibrillation: a hybrid computational/physiological study. Ann Biomed Eng. 2018; 46:257-269. (download)


Budday S, Sommer G, Hayback J, Steinmann P, Holzapfel GA, Kuhl E. Rheological characterization of human brain tissue. Acta Biomat. 2017; 60:315-329. (download)

van den Bedem H, Kuhl E. Molecular mechanisms of chronic traumatic encephalopathy. Curr Opinion Biomed Eng. 2017;1:23-30. (download)

Weickenmeier J, de Rooij R, Budday S, Ovaert TC, Kuhl E. The mechanical importance of myelination in the central nervous system J Mech Beh Biomed Mat. 2017; 76:119-124. (download)

Weickenmeier J, Fischer C, Carter D, Kuhl E, Goriely A. Dimensional, geometrical, and physical constraints in skull growth. Phys Rev Lett. 2017; 118:248101. (download) (focus) (phys org)

Kuo C, Wu LC, Ye PP, Laksari K, Camarillo D, Kuhl E. Pilot findings of brain displacements and deformations during roller coaster rides. J Neurotrauma. 2017; 34:3198-3205. (download)

Budday S, Sommer G, Holzapfel GA, Steinmann P, Kuhl E. Viscoelastic parameter identification of human brain tissue. J Mech Beh Biomed Mat. 2017; 74:463-476. (download)

Weickenmeier J, Saez P, Butler CAM, Young PG, Goriely A, Kuhl E. Bulging brains. J Elast. 2017; 129:197–212. (download)

Mihai LA, Budday S, Holzapfel GA, Kuhl E, Goriely A. A family of hyperelastic models for human brain tissue. J Mech Phys Solids. 2017;106:60-79. (download)

Budday S, Sommer G, Birkl C, Langkammer C, Hayback J, Kohnert J, Bauer M, Paulsen F, Steinmann P, Kuhl E, Holzapfel GA. Mechanical characterization of human brain tissue. Acta Biomat. 2017;48:319-340. (download)

de Rooij R, Miller KE, Kuhl E. Modeling molecular mechanisms in the axon. Comp Mech. 2017;59:523-537. (download)

Weickenmeier J, Butler CAM, Young PG, Goriely A, Kuhl E. The mechanics of decompressive craniectomy: Personalized simulations. Comp Meth Appl Mech Eng. 2017;314:180-195. (download)

Sahli Costabal F, Concha FA, Hurtado DE, Kuhl E. The importance of mechano-electrical feedback and inertia in cardiac electromechanics. Comp Meth Appl Mech Eng. 2017;320:352-368. (download)

Buganza Tepole A, Vaca EE, Purnell CA, Gart M, McGrath J, Kuhl E, Gosain A. Quantification of strain in a porcine model of skin expansion using multi-view stereo and isogeometric kinematics. JoVE. 2017;122:e55052. (download) (movie) (jove)

Budday S, Andres S, Walter B, Steinmann P, Kuhl E. Wrinkling instabilities in soft bi-layered systems. Phil Trans R Soc A. 2017;375:20160163. (download)

Rausch MK, Zollner AM, Genet M, Baillargeon B, Bothe W, Kuhl E. A virtual sizing tool for mitral valve annuloplasty. Int J Num Meth Biomed Eng. 2017;33:e02788. (download)

Holland MA, Li B, Feng XQ, Kuhl E. Instabilities of soft films on compliant substrates. J Mech Phys Solids. 2017;98:350-365. (download)


Kuhl E. Biophysics: Unfolding the brain. Nature Physics. 2016;12:533-534. (download) (los angeles times) (chicago tribune) (international business times) (spektrum)

Goriely A, Weickenmeier J, Kuhl E. Stress singularities in swelling soft solids. Phys Rev Lett. 2016;117:138001. (download) (stanford report) (oxford science blog) (press oxford) (engadget) (physics buzz) (i4u) (phys org) (neurosciences news) (science blog) (physics world)

Weickenmeier J, Kuhl E, Goriely A. The mechanics of decompressive craniectomy: Bulging in idealized geometries. J Mech Phys Solids. 2016;96:572-590. (download)

Narayan SM, Baykaner T, Sahli Costabal F, Kuhl E. Terminating atrial fibrillation by cooling the heart. Heart Rhythm. 2016;13:2259-2260. (download)

Weickenmeier J, de Rooij R, Budday S, Steinmann P, Ovaert TC, Kuhl E. Brain stiffness increases with myelin content. Acta Biomat. 2016;42:265-272. (download)

Lejeune E, Javili A, Weickenmeier J, Kuhl E, Linder C. Tri-layer wrinkling as a mechanism for anchoring center initiation in the developing cerebellum. Soft Matter. 2016;12:5613-5620. (download)

Ploch CC, Mansi CSSA, Jayamohan J, Kuhl E. Using 3D printing to create personalized brain models for neurosurgical training and preoperative planning. World Neurosurg. 2016;90:668-674. (download), (perspectives)

Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artificial Organs. 2016;39:421-430 (download) (open access)

Sahli Costabal F, Hurtado DE, Kuhl E. Generating Purkinje networks in the human heart. J Biomech. 2016;49:2455-2465. (download) (download code from github) (download code from simtk)

Eskandari M, Javili A, Kuhl E. Elastosis during airway wall remodeling explains multiple coexisting instability patterns. J Theor Bio. 2016;403:209-218. (download)

Buganza Tepole A, Gart M, Purnell CA, Gosain AK, Kuhl E. The incompatibility of living systems: Characterizing growth-induced incompatibilities in expanded skin. Ann Biomed Eng. 2016;44:1734-1752. (download)

de Rooij R, Kuhl E. Constitutive modeling of brain tissue: current perspectives. Appl Mech Rev. 2016;68:010801-1-010801-16. (download)

Saez P, Kuhl E. Computational modeling of acute myocardial infarction. Comp Meth Biomech Biomed Eng. 2016;19:1107-1115. (download)

Chabiniok R, Wang V, Hadjicharalambous M, Asner L, Lee J, Sermesant M, Kuhl E, Young A, Moireau P, Nash M, Chapelle D, Nordsletten DA. Multiphysics and multiscale modeling, data-model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics. Interface Focus. 2016;6:20150083. (download)

Genet M, Lee LC, Baillargeon B, Guccione JM, Kuhl E. Modeling pathologies of systolic and diastolic heart failure. Ann Biomed Eng. 2016;44:112-127. (download) (open access) (video)

Buganza Tepole A, Kuhl E. Computational modeling of chemo-bio-mechanical coupling: A systems-biology approach towards wound healing. Comp Meth Biomech Biomed Eng. 2016;19:13-30. (download)


van den Bedem H, Kuhl E. Tau-ism: the Yin and Yang of microtubule sliding, detachment, and rupture. Biophys J. 2015;109:2215-2217. (download)

Goriely A, Budday S, Kuhl E. Neuromechanics: from neurons to brain. Adv Appl Mech. 2015;48:79-139. (download)

Budday S, Steinmann P, Kuhl E. Secondary instabilities modulate cortical complexity in the mammalian brain. Phil Mag. 2015;95:3244-3256. (download)

Budday S, Kuhl E, Hutchinson JW. Period-doubling and period-tripling in growing bilayered systems. Phil Mag. 2015;95:3208-3224. (download)

Eskandari M, Kuhl E. Systems biology and mechanics of growth. WIREs Syst Biol Med. 2015;7:401-412. (download)

Budday S, Steinmann P, Goriely A, Kuhl E. Size and curvature regulate pattern selection in the mammalian brain. Extr Mech Lett. 2015;4:193-198. (download)

Buganza Tepole A, Gart M, Purnell CA, Gosain AK, Kuhl E. Multi-view stereo analysis reveals anisotropy of prestrain, deformation, and growth in living skin. Biomech Mod Mechanobio. 2015;14:1007-1019. (download)

Goriely A, Geers MGD, Holzapfel GA, Jayamohan J, Jerusalem A, Sivaloganathan S, Squier W, van Dommelen JAW, Waters S, Kuhl E. Mechanics of the brain: Perspectives, challenges, and opportunities. Biomech Mod Mechanobio. 2015;14:931-965. (download) (open access)

Eskandari M, Kuschner WG, Kuhl E. Patient-specific airway wall remodeling in chronic lung disease. Ann Biomed Eng. 2015;10:2538-2551. (download)

Javili A, Dortdivanlioglu B, Kuhl E, Linder C. Computational aspects of growth-induced instabilities. Comp Mech. 2015;56:405-420. (download)

Budday S, Steinmann P, Kuhl E. Physical biology of human brain development. Front Cell Neurosci. 2015;9:257. (download) (download) (open access)

Buganza Tepole A, Kabaria H, Bletzinger KU, Kuhl E. Isogeometric Kirchhoff-Love shell formulations for biological membranes. Comp Meth Appl Mech Eng. 2015;293:328-347. (download)

Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM. Human cardiac function simulator for the optimal design of a novel annuloplasty ring with a sub-valvular element for correction of ischemic mitral regurgitation. Cardiovasc Eng Tech. 2015;6:105-116. (download) (video)

Genet M, Rausch MK, Lee LC, Choy S, Zhao X, Kassab GS, Kozerke S, Guccione JM, Kuhl E. Heterogeneous growth-induced prestrain in the heart. J Biomech. 2015;48:2080-2089. (download)

Holland MA, Miller KE, Kuhl E. Emerging brain morphologies from axonal elongation. Ann Biomed Eng. 2015;43:1640-1653. (download)

Wong J, Kuhl E, Darve E. A new sparse matrix vector multiplication GPU algorithm designed for finite element problems. Int J Num Meth Eng. 2015;102:1784-1814. (download)

Budday S, Nay R, de Rooij R, Steinmann P, Wyrobek T, Ovaert TC, Kuhl E. Mechanical properties of gray and white matter brain tissue by indentation. J Mech Behavior Biomed Mat. 2015;46:318-330. (download)

Raaz U, Zöllner AM, Schellinger IN, Toh R, Nakagami F, Brandt M, Emrich FC, Kayama Y, Eken S, Adam M, Maegdefessel L, Hertel T, Deng A, Jagger A, Buerke M, Dalman RL, Spin JM, Kuhl E, Tsao PS. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development. Circulation. 2015;131:1783-1795. (download) (editorial)

Balbi V, Kuhl E, Ciarletta P. Morphoelastic control of gastro-intestinal organogenesis: theoretical predictions and numerical insights. J Mech Phys Solids. 2015;78:493-510. (download)

Wisdom KM, Delp SL, Kuhl E. Use it or lose it: Multiscale skeletal muscle adaptation to mechanical stimuli. Biomech Model Mechanobio. 2015;14:195-215. (download)

Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E. A computational model predicts reverse growth in response to mechanical unloading. Biomech Model Mechanobio. 2015;14:217-229. (download)

Zöllner AM, Pok JM, McWalter EJ, Gold GE, Kuhl E. On high heels and short muscles: A multiscale model for sarcomere loss in the gastrocnemius muscle. J Theor Bio. 2015;365:301–310. (download)

Checa S, Rausch MK, Petersen A, Kuhl E, Duda GN. The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization. Biomech Mod Mechanobio. 2015;14:1-13. (download)


Ciarletta P, Balbi V, Kuhl E. Pattern selection in growing tubular tissues. Phys Rev Lett. 2014;113:248101. (download) (synopsis) (computing the gut)

Buganza Tepole A, Gart M, Gosain AK, Kuhl E. Characterization of living skin using multi view stereo and isogeometric analysis. Acta Biomat. 2014;10:4822-4831. (download)

Buganza Tepole A, Steinberg JP, Kuhl E, Gosain AK. Application of finite element modeling to optimize flap design with tissue expansion. Plast Reconstr Surgery. 2014;134:785-792. (download)

Budday S, Steinmann P, Kuhl E. The role of mechanics during brain development. J Mech Phys Solids. 2014;72:75-92. (download) (open access)

Göktepe S, Menzel A, Kuhl E. The generalized Hill model: A kinematic approach towards active muscle contraction. J Mech Phys Solids. 2014;72:20-39. (download)

Baillargeon B, Rebelo N, Fox DD, Taylor RL, Kuhl E. The Living Heart Project: A robust and integrative simulator for human heart function. Eur J Mech A/Solids. 2014;48:38-47. (download) (open access) (movie)

Vogel F, Göktepe S, Steinmann P, Kuhl E. Modeling and simulation of viscous electro-active polymers. Eur J Mech A/Solids. 2014;48:112-128. (download)

Buganza Tepole A, Gosain AK, Kuhl E. Computational modeling of skin: Using stress profiles as predictor for tissue necrosis in reconstructive surgery. Comp & Struct. 2014;143:32-39. (download)

Budday S, Raybaud C, Kuhl E. A mechanical model predicts morphological abnormalities in the developing human brain. Sci Rep. 2014;4:5644. (download) (open access)

Saez P, Pena E, Martinez MA, Kuhl E. Computational modeling of hypertensive growth in the human carotid artery. Comp Mech. 2014;53:1183-1196. (download)

Wong J, Kuhl E. Generating fiber orientation maps in human heart models using Poisson interpolation. Comp Meth Biomech Biomed Eng. 2014;17:1217-1226. (download)

Hurtado DE, Kuhl E. Computational modelling of electrocardiograms: Repolarisation and T-wave polarity in the human heart. Comp Meth Biomech Biomed Eng. 2014;17:986-996. (download)

Rausch MK, Kuhl E. On the mechanics of growing thin biological membranes. J Mech Phys Solids. 2014;63:128-140. (download)

Kuhl E. Growing matter - A review of growth in living systems. J Mech Behavior Biomed Mat. 2014;29:529-543. (download)

Javili A, Steinmann P, Kuhl E. A novel strategy to identify the critical conditions for growth-induced instabilities. J Mech Behavior Biomed Mat. 2014;29:20-32. (download)


Eskandari M, Pfaller MR, Kuhl E. On the role of mechanics in chronic lung disease. Materials. 2013;6:5639-5658. (download) (open access)

Zöllner AM, Holland MA, Honda KS, Gosain AK, Kuhl E. Growth on demand - Reviewing the mechanobiology of stretched skin. J Mech Behavior Biomed Mat. 2013;28:495-509. (download)

Saez P, Pena E, Martinez MA, Kuhl E. Mathematical modeling of collagen turnover in biological tissue. J Math Bio. 2013;67:1765-1793. (download)

Wong J, Göktepe S, Kuhl E. Computational modeling of chemo-electro-mechanical coupling: A novel implicit monolithic finite element approach. Int J Num Meth Biomed Eng. 2013;29:1104-1133. (download)

Rausch MK, Famaey N, O'Brien Shultz T, Bothe W, Miller DC, Kuhl E. Mechanics of the mitral valve: A critical review, an in vivo parameter identification, and the effect of prestrain. Biomech Mod Mechanobio. 2013;12:1053-1071. (download)

Rausch MK, Tibayan FA, Ingels NB, Miller DC, Kuhl E. Mechanics of the mitral annulus in chronic ischemic cardiomyopathy. Ann Biomed Eng. 2013;41:2171-2180. (download)

Rausch MK, Kuhl E. On the effect of prestrain and residual stress in thin biological membranes. J Mech Phys Solids. 2013;61:1955-1969. (download)

Holland MA, Kosmata T, Goriely A, Kuhl E. On the mechanics of thin films and growing surfaces. Math Mech Solids. 2013;18:561-575. (download)

Papastavrou A, Steinmann P, Kuhl E. On the mechanics of continua with boundary energies and growing surfaces. J Mech Phys Solids, 2013;61:1446-1463. (download)

Buganza Tepole A, Kuhl E. Review: Systems-based approaches towards wound healing. Pediatric Res, 2013;73:553–563. (download)

Chen MQ, Wong J, Kuhl E, Giovangrandi L, Kovacs GTA. Characterization of electrophysiological conduction in cardiomyocyte co-cultures using co-occurrence analysis. Comp Meth Biomech Biomed Eng, 2013;16:185-197. (download)

Famaey N, Vander Sloten J, Kuhl E. A three-constituent damage model for arterial clamping in computer-assisted surgery. Biomech Mod Mechanobio, 2013;12:123-136. (download)

Dal H, Göktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electromechanics. Comp Meth Appl Mech Eng, 2013;253:323-336. (download)


Rausch MK, Tibayan FA, Miller DC, Kuhl E. Evidence of adaptive mitral leaflet growth. J Mech Behavior Biomed Mat, 2012;15:208-217. (download)

Zöllner AM, Abilez OJ, Böl M, Kuhl E. Stretching skeletal muscle - Chronic muscle lengthening through sarcomerogenesis. PLoS ONE, 2012;7(10):e45661. (download) (open access)

Bothe W, Rausch MK, Kvitting JP, Echtner DK, Walther M, Ingels NB, Kuhl E, Miller DC. How do annuloplasty rings affect mitral annular strains in the normal beating ovine heart? Circulation, 2012;126:S231-S238. (download)

Buganza Tepole A, Gosain AK, Kuhl E. Stretching skin - The physiological limit and beyond. Int J Nonlin Mech, 2012;47:938-949. (download)

Zöllner AM, Buganza Tepole A, Gosain AK, Kuhl E. Growing skin - Tissue expansion in pediatric forehead reconstruction. Biomech Mod Mechanobio, 2012;11:855-867. (download)

Waffenschmidt T, Menzel A, Kuhl E. Anisotropic density growth of bone. A computational micro-sphere approach. Int J Solids Structures, 2012;49:1928-1946. (download)

Menzel A, Kuhl E. Frontiers in growth and remodeling. Mech Res Comm, 2012;42,1-14. (download)

Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM. Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration. Mech Res Comm, 2012;42,134-141. (download)

Dal H, Göktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electrophysiology. Comp Meth Biomech Biomed Eng, 2012;15,645-656. (download)

Wong J, Abilez OJ, Kuhl E. Computational optogenetics - A novel continuum framework for the photoelectrochemistry of living systems. J Mech Phys Solids, 2012;60:1158-1178. (download)

Schmid H, Pauli L, Paulus A, Kuhl E, Itskov M. Consistent formulation of the growth process at the kinematic and constitutive level for soft tissues composed of multiple constituents. Comp Meth Biomech Biomed Eng, 2012;15:547-561. (download)

Tsamis A, Cheng A, Nguyen TC, Langer F, Miller DC, Kuhl E. Kinematics of cardiac growth - In vivo characterization of growth tensors and strains. J Mech Behavior Biomed Mat, 2012;8:165-177. (download)

Zöllner AM, Buganza Tepole A, Kuhl E. On the biomechanics and mechanobiology of growing skin. J Theor Bio, 2012;297:166-175. (download)

Rausch MK, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Mitral valve annuloplasty - A quantitative clinical and mechanical comparison of different annuloplasty devices. Ann Biomed Eng, 2012;40:750-761. (download)

Pang H, Shiwalkar AP, Madormo CM, Taylor RE, Andriacchi TP, Kuhl E. Computational modeling of bone density profiles in response to gait: A subject-specific approach. Biomech Mod Mechanobio, 2012;11:379-390. (download)

Böl M, Abilez OJ, Assar AN, Zarins CK, Kuhl E. In vitro / in silico characterization of active and passive stresses in cardiac muscle. Int J Multiscale Comp Eng, 2012;10:171-188. (download)


Rausch MK, Dam A, Göktepe S, Abilez OJ, Kuhl E. Computational modeling of growth: Systemic and pulmonary hypertension in the heart. Biomech Mod Mechanobio, 2011;10:799-811. (download)

Buganza Tepole A, Ploch CJ, Wong J, Gosain AK, Kuhl E. Growing skin - A computational model for skin expansion in reconstructive surgery. J Mech Phys Solids, 2011;59:2177-2190. (download) (online)

Wong J, Göktepe S, Kuhl E. Computational modeling of electrochemical coupling: A novel finite element approach towards ionic models for cardiac electrophysiology. Comp Meth Appl Mech Eng, 2011;200:3139-3158. (download)

Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E. Multiscale computational models for optogenetic control of cardiac function. Biophys J, 2011;101:1326-1334. (download) (open access) (report)

Bothe W, Kuhl E, Kvitting JP, Rausch MK, Göktepe S, Swanson JC, Farahmandnia S, Ingels NB, Miller DC. Rigid, complete annuloplasty rings increase anterior mitral leaflet strains in the normal beating ovine heart. Circulation, 2011;124:S81-S96. (download)

Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. Ann Thorac Surg, 2011;92:935-941. (download)

Tsamis A, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Active contraction of cardiac muscle: In vivo characterization of mechanical activation sequences in the beating heart. J Mech Behavior Biomed Mat, 2011;4:1167-1176. (download)

Rausch MK, Bothe W, Kvitting JP, Swanson JC, Ingels NB, Miller DC, Kuhl E. Characterization of mitral valve annular dynamics in the beating heart. Ann Biomed Eng, 2011;39:1690-1702. (download)

Rausch MK, Bothe W, Kvitting JP, Göktepe S, Miller DC, Kuhl E. In vivo dynamic strains of the ovine anterior mitral valve leaflet. J Biomechanics, 2011;44:1149-1157. (download)

Ambrosi D, Ateshian GA, Arruda EM, Cowin SC, Dumais J, Goriely A, Holzapfel GA, Humphrey JD, Kemkemer R, Kuhl E, Olberding JE, Taber LA, Garikipati K. Perspectives on biological growth and remodeling. J Mech Phys Solids, 2011;59:863-883. (download)

Göktepe S, Acharya SNS, Wong J, Kuhl E. Computational modeling of passive myocardium. Int J Num Meth Biomed Eng, 2011;27:1-12. (download)


Kvitting JP, Bothe W, Göktepe S, Rausch MK, Swanson JC, Kuhl E, Ingels NB, Miller DC. Anterior mitral leaflet curvature during the cardiac cycle in the normal ovine heart. Circulation, 2010;122:1683-1689. (download)

Göktepe S, Abilez OJ, Kuhl E. A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening. J Mech Phys Solids, 2010;58:1661-1680. (download)

Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Bio, 2010;265:433-442. (download)

Rajagopal A, Fischer P, Kuhl E, Steinmann P. Natural element analysis of the Cahn-Hilliard phase-field model. Comp Mech, 2010;46:471-493. (download)

Göktepe S, Bothe W, Kvitting JP, Swanson J, Ingels NB, Miller DC, Kuhl E. Anterior mitral leaflet curvature in the beating ovine heart. A case study using videofluoroscopic markers and subdivision surfaces. Biomech Mod Mechanobio, 2010;9:281-293. (download)

Kotikanyadanam M, Göktepe S, Kuhl E. Computational modeling of electrocardiograms - A finite element approach towards cardiac excitation. Int J Num Meth Biomed Eng, 2010;26:524-533. (download)

Gitman I, Askes H, Kuhl E, Aifantis EC. Stress concentrations in fractured compact bone simulated with a special class of anisotropic gradient elasticity. Int J Solids Structures, 2010;47:1099-1107. (download)

Göktepe S, Wong J, Kuhl E. Atrial and ventricular fibrillation - Computational simulation of spiral waves in cardiac tissue. Arch Appl Mech, 2010;80:569-580. (download)

Zhang J, Michalenko MM, Kuhl E, Ovaert TC. Characterization of indentation response and stiffness reduction of bone using a continuum damage model. J Mech Behavior Biomed Mat, 2010;3:189-202. (download)

Göktepe S, Kuhl E. Electromechanics of the heart - A unified approach to the strongly coupled excitation-contraction problem. Comp Mech, 2010;45:227-243. (download)


Krishnamurthy G, Itoh A, Swanson J, Bothe W, Karlsson M, Kuhl E, Miller DC, Ingels NB. Regional stiffening of the mitral valve anterior leaflet in the beating heart. J Biomechanics, 2009;42:2697-2701. (download)

Jager P, Steinmann S, Kuhl E. Towards the treatment of boundary conditions for global crack path tracking in three-dimensional brittle fracture. Comp Mech. 2009;45:91-107. (download)

Krishnamurthy G, Itoh A, Bothe W, Swanson J, Kuhl E, Karlsson M, Miller DC, Ingels NB. Stress-strain behavior of mitral valve leaflets in the beating ovine heart. J Biomechanics. 2009;42:1909-1916. (download)

Itoh A, Krishnamurthy G, Swanson J, Ennis D, Bothe W, Kuhl E, Karlsson M, Davis L, Miller DC, Ingels NB. Active stiffening of mitral valve leaflets in the beating heart. Am J Physiol Heart Circ Physiol. 2009;296:H1766-H1773. (download)

Göktepe S, Kuhl E. Computational modeling of electrophysiology: A novel finite element approach. Int J Num Meth Eng. 2009; 79:156-178. (download)

Böl M, Reese S, Parker KK, Kuhl E. Computational modeling of muscular thin films for cardiac repair. Comp Mech. 2009;43:535-544. (download)

Taylor RE, Zheng C, Jackson PR, Doll JC, Chen JC, Holzbaur KRS, Besier T, Kuhl E. The phenomenon of twisted growth: Humeral torsion in dominant arms of high performance tennis players. Comp Meth Biomech Biomed Eng. 2009;12:83-93. (download)


Krishnamurthy G, Ennis DB, Itoh A, Bothe W, Swanson-Birchill JC, Karlsson M, Kuhl E, Miller DC, Ingels NB. Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis. Am J Physiol Heart Circ Physiol. 2008;295:H1141-H1149. (download)

Jha CM, Salvia J, Chandorkar SA, Melamud R, Kuhl E, Kenny TW. Acceleration insensitive encapsulated silicon microresonator. Appl Phys Let. 2008;93:234103.1-234103.3. (download)

Jager P, Schmalholz SM, Schmid DW, Kuhl E. Brittle fracture during folding rocks - A finite element study. Phil Mag. 2008;88:3245-3263. (download)

Meier HA, Schlemmer M, Wagner C, Kerren A, Hagen H, Kuhl E, Steinmann P. Visualization of particle interactions in granular media. IEEE Trans Vis Comp Graphics. 2008;14:1-16. (download)

Jager P, Steinmann P, Kuhl E. Modeling three-dimensional crack propagation - A comparison of crack path tracking strategies. Int J Num Meth Eng, 2008;76:1328-1352. (download)

Himpel G, Menzel A, Kuhl E, Steinmann P. Time-dependent fiber reorientation of transversely isotropic continua - Finite element formulation and consistent linearization. Int J Num Meth Eng. 2008;73:1413-1433. (download)

Jager P, Steinmann P, Kuhl E. On local tracking algorithms for the simulation of three-dimensional discontinuities. Comp Mech, 2008;42:395-406. (download)

Meier HA, Steinmann P, Kuhl E. Towards mulitscale computation of confined granular media - Contact forces, stresses and tangent operators. Techn Mech. 2008;28:32-42. (download)

Utzinger J, Bos M, Floeck M, Menzel A, Kuhl E, Renz R, Friedrich K, Schlarb AK, Steinmann P. Computational modelling of thermal impact welded PEEK/steel single lap tensile specimens. Comp Mat Sci. 2008;41:287-296. (download)

Meier HA, Kuhl E, Steinmann P. A note on the generation of periodic granular microstructures based on grain size distributions. Int J Num Anal Meth Geomech. 2008;32:509-522. (download)


Kuhl E, Holzapfel GA. A continuum model for remodeling in living structures. J Mat Sci. 2007;42:8811-8823. (download)

Hauret P, Kuhl E, Ortiz M. Diamond elements: A finite-element / discrete-mechanics approximation scheme with guaranteed optimal convergence in incompressible elasticity. Int J Num Meth Eng. 2007;72:253-294. (download)

Kuhl E, Maas R, Himpel G, Menzel A. Computational modeling of arterial wall growth: Attempts towards patient specific simulations based on computer tomography. Biomech Mod Mechanobio. 2007;6:321-331. (download)

Hirschberger CB, Kuhl E, Steinmann P. On deformational and configurational mechanics of micromorphic hyperelasticity - Theory and computation. Comp Meth Appl Mech Eng. 2007;196:4027-4044. (download)

Kuhl E, Schmid DW. Computational modeling of mineral unmixing and growth - An application of the Cahn-Hilliard equation. Comp Mech. 2007;39:439-451. (download)

Mergheim J, Kuhl E, Steinmann P. Towards the algorithmic treatment of 3D strong discontinuities. Comm Num Meth Eng. 2007;23:97-108. (download)


Wells G, Kuhl E, Garikipati K. A discontinuous Galerkin formulation for the Cahn-Hilliard equation. J Comp Phys. 2006;218:860-877. (download)

Kuhl E, Menzel A, Garikipati K. On the convexity of transversely isotropic chain network models. Phil Mag. 2006;86:3241-3258. (download)

Kuhl E, Askes H, Steinmann P. An illustration of the equivalence of the loss of ellipticity conditions in spatial and material settings of hyperelasticity. Eur J Mech/A: Solids. 2006;25:199-214. (download)


Kuhl E, Garikipati K, Arruda EM, Grosh K. Remodeling of biological tissue - Mechanically induced reorientation of a transversely isotropic chain network. J Mech Phys Solids. 2005;53:1552-1573. (download)

Kuhl E, Balle F. Computational modeling of hip replacement surgery - Total hip replacement vs. hip resurfacing. Techn Mech. 2005;25:107-114. (download)

Himpel G, Kuhl E, Menzel A, Steinmann P. Computational modelling of isotropic multiplicative growth. CMES Comp Model Eng Sci. 2005;8:119-134. (download)

Mergheim J, Kuhl E, Steinmann P. A finite element method for the computational modelling of cohesive cracks. Int J Num Meth Eng. 2005;63:276-289. (download)

Kuhl E, Steinmann P. A hyperelastodynamic ALE formulation based on referential, spatial and material forces. Acta Mech. 2005;174:201-222. (download)

Askes H, Bargmann S, Kuhl E, Steinmann P. Structural optimisation by simultaneous equilibration of spatial and material forces. Comm Num Meth Eng. 2005:21;433-442. (download)


Kuhl E, Steinmann P. Computational modeling of healing - An application of the material force method. Biomech Mod Mechanobio. 2004;2:187-203. (download)

Kuhl E, Askes H, Steinmann P. An ALE formulation based on spatial and material settings of continuum mechanics, Part 1: Generic hyperelastic formulation. Comp Meth Appl Mech Eng. 2004;193:4207-4222. (download)

Askes H, Kuhl E, Steinmann P. An ALE formulation based on spatial and material settings of continuum mechanics, Part 2: Classification and applications. Comp Meth Appl Mech Eng. 2004;193:4223-4245. (download)

Kuhl E, Denzer R, Barth FJ, Steinmann P. Application of the material force method to thermo-hyperelasticity. Comp Meth Appl Mech Eng. 2004;193:3303-3326. (download)

Mergheim J, Kuhl E, Steinmann P. A hybrid discontinuous Galerkin/interface method for the computational modelling of failure. Comm Num Meth Eng. 2004;20:511-519. (download)

Kuhl E, Steinmann P. Material forces in open system mechanics. Comp Meth Appl Mech Eng. 2004;193:2357-2381. (download)


Kuhl E, Menzel A, Steinmann P. Computational modeling of growth - A critical review, a classification of concepts and two new consistent approaches. Comp Mech. 2003;32:71-88. (download)

Kuhl E, P Steinmann P. Theory and numerics of geometrically nonlinear open systems Int J Num Meth Eng. 2003;58:1593-1615. (download)

Kuhl E, Steinmann P. On spatial and material settings of thermo-hyperelastodynamics for open systems. Acta Mech. 2003;160:179-217. (download)

Kuhl E, Steinmann P. Mass- and volume specific views on thermodynamics for open systems. Proc Roy Soc. 2003;459:2547-2568. (download)

Kuhl E, Hulshoff S, de Borst R. An arbitrary Lagrangian Eulerian finite-element approach for fluid-structure interaction phenomena. Int J Num Meth Eng. 2003;57:117-142. (download)


Kuhl E, Carol I, Steinmann P. New thermodynamic approach to microplane model. Part II: Dissipation and inelastic constitutive modelling. Int J Solids Structures. 2001;38:2933-2952. (download)


Kuhl E, Ramm E, Willam KJ. Failure analysis for elasto-plastic material models on different levels of observation. Int J Solids Structures. 2000;37:7259-7280. (download)

Kuhl E, Ramm E, de Borst R. An anisotropic gradient damage model for quasi-brittle materials. Comp Meth Appl Mech Eng. 2000;183:87-103. (download)

Kuhl E, Ramm E. Microplane modelling of cohesive frictional materials. Eur J Mech/A:Solids; 2000;19:S121-S143. (download)

Kuhl E, D'Addetta GA, Herrmann HJ, Ramm E. A comparison of discrete granular material models with continuous microplane formulations. Granular Matter. 2000;2:123-135. (download)


Kuhl E, Ramm E. Simulation of strain localization with gradient enhanced damage models. Comp Mat Sci. 1999;16:176-185. (download)

Mahnken R, Kuhl E. Parameter identification of gradient enhanced damage models with the finite element method. Eur J Mech/A: Solids. 1999;18:819-835. (download)


Kuhl E, Ramm E. On the linearization of the microplane model. Mech Coh Fric Mat. 1998;2:343-364. (download)

Steinmann P, Kuhl E, Stein E. Aspects of non-associated single crystal plasticity: Influence of Non-Schmid effects and localization analysis. Int J Solids Structures. 1998;35:4437-4456. (download)


Sawischlewski E, Steinmann P, Stein E. Modelling and computations of instability phenomena in multisurface plasticity. Comp Mech. 1996;18:245-258. (download)

habilitation thesis

Kuhl E. Theory and numerics of open system thermodynamics - Spatial and material settings. TU Kaiserslautern. 2004. (download)

co-authors in a box

professor harm askes (university of sheffiled, uk), professor paul steinmann (university of erlangen-nuremberg, germany), professor dani schmid (university of oslo, norway), professor swantje bargmann (tu hamburg harburg, germany), professor bert sluys (tu delft, the netherlands), m sc alberto bordallo (tu delft, the netherlands), professor julia mergheim (university of erlangen-nuremberg, germany), dr ing rouven mohr (tu kaiserslautern, germany), dr ing holger meier (tu kaiserslautern, germany), professor angelo simone (tu delft, the netherlands), dr terry bennett (university of sheffield, uk), dr ir martijn stroeven (tu delft, the netherlands), dr ing grieta himpel (tu kaiserslautern, germany), professor andreas menzel (tu dortmund, germany), professor sigrid leyendecker (university of erlangen-nuremberg, usa), professor akke suiker (tu eindhoven, the netherlands), dr ing philippe jaeger (tu kaiserslautern, germany)