winter 19 - me337 - mechanics of growth

me 337 - mechanics of growth 19 oguz tikenogullari ellen kuhl winter 2019 tue/thu 10:30-11:50, 380-380W office hours tbd, 520-203 / 520-204 course announcement

goals

growth is a distinguishing feature of all living things. this course introduces the concept of living systems through the lens of mechanics. we discuss the basic continuum theory for living systems including the kinematics, balance equations, and constitutive equations and the computational modeling of growth phenomena including growing plants, remodeling bone, healing wounds, growing tumors, atherosclerosis, expanding skin, failing hearts, developing brains, and the effects of high performance training.

journal club

mechanics of growth on imechanica

class papers

harris tc, de rooij r, kuhl e. the shrinking brain: cerebral atrophy following traumatic brain injury. ann biomed eng, 2018;doi:10.1007/s10439-018-02148-2. (download)

zöllner am, pok jm, mcwalter ej, gold ge, kuhl e. on high heels and short muscles: a multiscale model for sarcomere loss in the gastrocnemius muscle. j theor bio, 2015;365:301–310. (download)

eskandari m, pfaller mr, kuhl e. on the role of mechanics in chronic lung disease. materials, 2013;6:5639-5658. (download) (open access)

zöllner am, abilez oj, böl m, kuhl e. stretching skeletal muscle - chronic muscle lengthening through sarcomerogenesis. plos one, 2012;7(10):e45661. (download) (open access)

pang h, shiwalkar ap, madormo cm, taylor re, andriacchi tp, kuhl e. computational modeling of bone density profiles in response to gait: a subject-specific approach. biomech model mechanobio, 2012;11:379-390. (download)

buganza tepole a, ploch cj, wong j, gosain ak, kuhl e. growing skin - a computational model for skin expansion in reconstructive surgery. j mech phys solids, 2011;59:2177-2190. (download)

taylor re, zheng ch, jackson pr, doll jc, chen jc, holzbaur krs, besier t, kuhl e. the phenomenon of twisted growth: humeral torsion in dominant arms of high performance tennis players. comp meth biomech biomed eng, 2009;12:83-93. (download)

grading

• 30 % homework - 3 homework assignments, 10% each
  
• 30 % final exam - closed book, closed notes, one single page cheat sheet
  
• 20 % final project oral presentations - graded by the class
  
• 20 % final project essay - graded by rijk and ellen

syllabus

final project

buganza a, wong j, kuhl e. computational modeling of mechanically driven skin growth due to different expander geometries, farmington, pennsylvania, 2011

matlab files

finally... here's the matlab code for growth

additional reading

(1) taber l. biomechanics of growth, remodeling, and morphogenesis, appl mech rew 48, 487-545, 1995
(2) kuhl e, menzel a, steinmann p. computational modeling of growth - a critical review, a classification and two new consistent approaches, computational mechanics 32, 71-88, 2003
(3) rodriguez ek, hoger a, mc culloch a. stress-dependent finite growth in soft elastic tissues, j biomechanics 27, 455-467, 1994
(4) kuhl e, maas r, himpel g, menzel a. computational modeling of arterial wall growth - attempts towards patient-specific simulations based on computer tomography, biomech model mechanobio 6, 321-331, 2007
(5) göktepe s, abilez oj, parker kk, kuhl e. a multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.j theor bio 265: 433-442, 2010
(6) ambrosi d, ateshian ga, arruda em, cowin sc, dumais j, goriely a, holzapfel ga, humphrey jd, kemkemer r, kuhl e, olberding je, taber la, garikipati k. perspectives on biological growth and remodeling.j mech phys solids 59: 863-883, 2011
(7) zöllner am, buganza tepole A, kuhl e. on the biomechanics and mechanobiology of growing skin. j theor bio 297, 166-175, 2012
(8) menzel a, kuhl e. frontiers in growth and remodeling. mech res comm 42,1-14, 2012